There are several drug classes that have been used in the treatment of gus, including proton pump inhibitors, m 1 receptor blockers, and h 2 receptor antagonists. Ethanol hcl induced gastric mucosal injury in rats. Study of anti ulcer activity of sodium metavanadate on alcohol and pylorus ligation induced gastric ulcers in rats p. Alphaboswellic acid protects against ethanolinduced. What is the possible therapeutic effect of ginkgo biloba. The ulcer index parameter was used for the evaluation of ulcer activity. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanol induced gastric ulcers in rats. Pdf protective role of phoenix dactylifera fruit against. Administration with weac not only markedly increased the activities of cat, sod, and gsh, decreased the level of mda, but also reduced the productions of tnf. Ethanolinduced gastric ulcer in rats and intervention of. Moreover, oxidative stress and inflammatory markers were elevated in the ulcer. Allanblackia floribunda seed extract attenuates the. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal group, cmc as ulcer group, 20 mgkg of omeprazole as positive group, 62. These findings suggest that gse exerted a potential curative effect against etoh induced gastric ulcer due in part to its antioxidants properties.
Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Six rats in each group were euthanized by decapitation. Pdf gallic acid 3,4,5trihydroxybenzoic acid, ga is a phenolic. Ulcers were induced by indomethacin, cytodestructive agents 80% ethanol, 0. Two calciumchannel blockers, verapamil and nicardipine, prevented stress induced increase in gastric lp, as well as ulcer formation. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of j. Seventyeight sd rats were randomly divided into 3 groups 6 in the blank group, 36 in the normal group, and 36 in the ethanol induced ulcer group for tissue sample collection at 0. Mechanisms of gastroprotective effects of ethanolic leaf.
Pdf ulceroprotective effect of methanol extract of psidium. Chitosancoated plga nanoparticles dispersion at a dose equivalent to 100 mgkg of diosmin p. Antiulcerogenic effect of cuphea ignea extract against. The present study investigates the anti ulcer activity of methanol extract of p. Evaluation of antiulcer activity of methanolic extract of. Gastric ulcer, gse, oxidative stress, fatty acids, rat. Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute ethanol 1. Ranitidine, maalox and misoprostol were used as standard drugs. Role of neutrophils in a rat model of gastric ulcer. Amelioration of ethanolinduced gastric ulcers in rats pretreated. Antiulcerogenic activity of scutia buxifolia on gastric. Studies on the mechanism of ethanolinduced gastric damage in. Protective role of phoenix dactylifera fruit against ethanol induced gastric ulcer in wistar rats. Ba against ethanol induced gastric injury in rats and attempts to explain the antioxidative mechanisms.
Calcium channel blockers prevent stressinduced ulcers in rats. Pdf protective effect of falcaria vulgaris extract on. Introduction stomach ulcers, one of the most common gastro. Pdf on jan 12, 2019, neda sistani karampour and others published gastroprotective effects of pistacia atlantica extract. Compositae hydroalcoholic extract mce on ethanol induced gastric mucosal injury were investigated in rats. Protective effect of matricaria chamomilla on ethanolinduced. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats. After 4 h of surgery, rats were sacrificed and ulcer scoring was done. The aqueous and methanol extracts of piptadeniastrum africanum were administered at the doses 125, 250 and 500 mgkg to evaluate their effects on gastric ulcer induced by the hcl ethanol mixture, indomethacin and acetic acid in wistar strain male adult rats, aged between 12 and 16 weeks and weighing between 180 and 220 g.
Pdf investigation of polyisoprenyl benzophenone for anti. Gastroprotective effect of carob ceratonia siliqua l. Antiulcer activity of steamed ginger extract against ethanolhcl. Microscopic observation of restraint induced ulcer rat stomach pretreated with ocimum sanctum 100mgkg 100xs. There are reports of its therapeutic use against ethanol induced gastric damage in rats. The animals were given standard rat pellets and ta. Antiulcerogenic activity of moringa oleifera root extract. Daniel hollander and his colleagues induced ulcer with ethanol in rats to evaluate the gastroprotective. This study aimed at investigating the gastroprotective effects of manuka honey against ethanol induced gastric ulcers in rats. The worldwide incidence of a gastric ulcer is high, most often as a result of use. Gastric ulcers are among the most common diseases affecting humans. Ghrelin protects against ethanolinduced gastric ulcers in.
Healing of acetic acid induced gastric ulcer and gastric mucosal pgi2 level in rats. All the animals were fasted for 36 hours before administration of ethanol. Article information, pdf download for ethanolinduced gastric ulcer in rats and intervention of tert. Antiulcerogenic effects of celosia trigyna plant extracts on. These effects were examined through gross macroscopic evaluation of the stomach cavity gastric ulcer index gui, alteration in ph, gastric juice volume, free acidity, total. A zinc morpholine complex prevents hcl ethanol induced gastric ulcers in a rat model. Electroacupuncture against ethanol induced gastric ulcer in rats. Both calciumchannel blockers protected against stress induced ulcers, and inhibition of lp may be among. In classical studies, ethanol induced gu animal models are often used to screen for compounds that possess anti ulcer activity. Studies on the mechanism of ethanolinduced gastric. Pdf gastroprotective effect of gallic acid against ethanolinduced.
Allanblackia floribunda seed extract attenuates the ethanol. Pdf gastroprotective effect of zingerone on ethanolinduced. Article information, pdf download for ethanol induced gastric ulcer in rats and intervention of tert. The mechanism by which honey exerts its antiulcer potential was elucidated. According to body weight, rats were pretreated with ra extracts 2. Taken together, the findings of this research amply demonstrated that weac exerted appreciable gastroprotective effect against ethanolinduced gastric ulcer in rats. The animals were sacrificed under anesthesia, and the. Rats were pretreated with three doses of aqueous extract of a. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Can misoprostol and omeprazole reduce nicotine and ethanol. Effects of nigella sativa oil on gastric secretion and. Antioxidant can donate a hydrogen atom to reduce free radi. Antioxidative and antiinflammatory effects of water. Effect and mechanism of ethanol extracts of muxiang radix.
To explore the possible mechanisms of action, we examined antioxidant defense enzymes e. Histological study of the absolute ethanol induced gastric mucosal damage in rats. Gastric juice was collected and gastric secretion studies were performed. Ethanol administration in rats, produced 100% ulcer induction with a mean ulcer score of 12. It has been found that oxygenderived free radicals are implicated in the mechanism of acute and chronic ulceration in the stomach umamaheswari et al. In the present investigation, an ethanol extract of celery apium graveolens l. Evaluation of anti ulcer activity of ethanolic extract of. Kaempferol protects ethanolinduced gastric ulcers in mice. Pdf screening the efficacy of some east himalayan medicinal. Pdf leaves extract of muntingia calabura protects against.
The findings suggest that sulfasalazine may be useful in treating gastric lesions cho et al. Diosmin protects against ethanolinduced gastric injury in. Twenty nine adult non pregnant female wistar rats weighing between 160225 gm were used for. Results antiulcer study gross estimations the results that pretreated with c. The animals were sacrificed under anesthesia, and the stomach and blood were collected. Apr 19, 2020 ulcer induction showed increase in hmgb1 expression through activation of nucleotide. Effects on gastric contractility and in the levels of tnf. This pdf is available for free download from a site hosted by medknow publications. Induction of rats with ethanol resulted in a significant rise in ulcer index, serum. Gastric ulcer is a chronic disease and serious health issue.
Administration of ethanolic extract of aegle marmelos and standard drug omeprazole both produced highly significant p ulcer effect compared to. The concentrations of drug were prepared in such a way that each rat. Protective effects of manassantin a against ethanol. Alphaboswellic acid protects against ethanolinduced gastric. Antioxidant, antiinflammatory, and antiulcer potential of. Ameliorating and protective effects mesalazine on ethanol. After the induction of gastric mucosal injury, all groups were sacrificed. Ameliorative, antioxidant, antiinflammatory, blighia sapida, cimetidine, gastric ulcer. Ghrelin exhibited a dosedependent protective effect against etoh induced gastric ulcers, with a significant inhibition compared with the saline group at a dose of 40 ng rat 39% and maximal inhibition at a dose. Celosia trigyna is a medicinal plant used traditionally for wound healing. All rats were fasted for 24 h with free access to drinking water and were treated as described in section 2. Phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. Gastroprotective effects of corchorus olitorius leaf. Ethanol is metabolized in the body and releases superoxide anion and hydroperoxy free radicals.
Protective effects of dids against ethanolinduced gastric. Antiulcerogenic effect of camel milk against ethanol induced. Protective effect of snail secretion filtrate against. Ethanol induced ulcer model 22 the ulcer was induced by administering ethanol. Electroacupuncture against ethanolinduced gastric ulcer in. Oral administration of camel milk in rats with ethanol induced gastric ulcer.
Gastric ulceration was induced using 80% ethanol after a pilot study was done to identify which ulcer inducing agents would induce the most ulceration with minimal mortality in one hour. Ethanol induced gastric mucosal ulceration in rats. Antioxidative and antiinflammatory effects of water extract. Ethanol induced acute gastric lesions are characterized by pathological changes, such as hemorrhage, edema, inflammatory infiltration, and epithelial cell loss. The ulcer areas seen in the rats treated with znlscn were significantly lower p download free pdf. Effects of aqueous extract of blighia sapida leaves on. Introduction gastric ulcer is a common global health problem both in terms of morbidity and mortality, occurring as a. A zinc morpholine complex prevents hclethanolinduced. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia.
Moreover, there was a significant increase in gastric mucosal histamine content without any significant change in peptic activity. Antioxidant and antiulcer effects of ethyl acetate fraction of. The antiulcerogenic and antioxidant properties of matricaria chamomilla l. Pdf cytoprotective activities of polygonum minus aqueous. To investigate the effect of ethanol extracts of muxiang radix aucklandiae ra on gastric ulcers in rats and explore the potential mechanisms. Induction of rats with ethanol resulted in a significant rise in ulcer. Pdf gastroprotective effects of pistacia atlantica extract on. Therapeutic effect of momordica balsamina leaf extract on.
Gastric antiulcer, antisecretory and cytoprotective. The effects of ethanol were evaluated by measuring the gastric secretion volume, ph, pepsin activity, and ulcer area. Mar 30, 2015 liu y, tian x, gou l, fu x, li s, lan n, et al. In the current study, we evaluated the therapeutic potential of sinapic acid sa in terms of the mechanism underlying its gastroprotective action against ethanol induced gastric ulcers in rats. Acidity of gastric content, the gastric wall mucus, ulcer areas, and histology and. Sixty minutes before ulcer induction, rats were treated with either 1 ml 10% tween80 as vehicle or ca 100, 250 or 500 mgkg dissolved in 1 ml vehicle, per oral fig. Antiulcerogenic effect of camel milk against ethanol. Jan 01, 2015 po dosage was selected based on a preliminary dosing experiment on ethanol induced ulceration. Following an 18h fasting period, ulcer was induced by oral gavage of 1 ml absolute ethanol in ulcer groups while control group received 1 ml tap water. Ethanol induced gu in animal model resembles the pathophysiology of human ulcer. Electroacupuncture against ethanolinduced gastric ulcer. Ethanol induced gastric mucosal lesions can be produced reliably by intragastric administration of varying amounts 0. There is moderate to severe disruption to the surface.
The effect of oral administration of raw camel milk 5 mlkg b. The anti ulcer study was evaluated using ethanol induced gastric ulcer in rats. Dec 05, 2020 sulfasalazine is used to treat ulcerative colitis. Study of anti ulcer activity of sodium metavanadate on.
But so far, there have been no reports of pretreatment effects of 5asa on ethanol induced gastric ulcer. Protective effects of pogostone from pogostemonis herba. Thirty wistar rats were divided into six groups of five rats each. The rats were administered 95% ethanol orally after 1 h. Jan 25, 2021 following an 18h fasting period, ulcer was induced by oral gavage of 1 ml absolute ethanol in ulcer groups while control group received 1 ml tap water. Mect was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. Rats were killed by cervical dislocation at vari ous times up to 1 h thereafter. Gastric ulcer gu is the most common health concern that occurs due to alcohol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level p induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine.
Evaluation of gastroprotective activity of myristica. Prophylactic efficacy of patchoulene epoxide against. Therefore the effect of vanillin was studied in experimental gastric ulcer. Molecules free fulltext preventative and therapeutic. The investigation was to evaluate gastroprotective effects of ethanolic extract of m. The albino rats of either sex were divided into five groups, each consisting of six rats. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs and by environmental and life style factors prabhu and shivani 2014. Animals described as fasted were deprived of food for 24 h, but had free. Ethanol induced tissue damage in rodents is a useful model for evaluation of ethanol induced pathologic changes in gastric mucosa.
Antiulcerogenic effect of cuphea ignea extract against ethanol. Gastroprotective effect of gallic acid against ethanolinduced gastric. Vanillin abrogates ethanol induced gastric injury in rats via. Caffeic acid attenuates gastric mucosal damage induced by. Methods animalswistar albino rats of both sexes 250300 g. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. The rats fasted for 24 hours but were allowed free access to drinking water up till 2. Biochanin a gastroprotective effects in ethanolinduced. The animals were given standard rat pellets and tap water. As a pretreatment, the negative control and the ulcer control groups were orally. Ethanol induced gastric ulcers serve as a common ulcerogenic agent. Ethanolinduced gastric ulcer in rats and intervention of tert.
This study aimed to isolate the bioactive compounds from celosia trigyna and to investigate the in vitro and in vivo antiulcerogenic effects of the extracts on ethanol induced gastric ulcer on adult wistar rats to determine their. Gastroprotective effect of sinapic acid on ethanolinduced. Stomachs were removed, opened along the greater curvature, and rinsed in saline. The effects of icv injections of ghrelin on gastric ulcers induced by etoh and assessed by macroscopical evaluation are shown in fig. Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation lp and decrease in gastric glutathione levels. One group represented the control group, which received ethanol. The present results demonstrate that the ethanolic extract of m. The gastro protective effects of cibotium barometz hair on.
Evaluation of newly formulated antiulcer drug on experimental. Abstract we compared the effects of misoprostol, omeprazole and methylcellulose control on gastric mucosal injury induced by nicotine andor ethanol. Jul 27, 2016 the effect of znlscn on the ulcer area induced by hcl ethanol is shown in fig. Amelioration of ethanolinduced gastric ulcers in rats. Protective effect of snail secretion filtrate against ethanol. The present study was designed to investigate the cytoprotective and antiinflammatory properties of tertbutylhydroquinone tbhq, a nuclear factor erythroid 2related factor 2 nrf2 activator, against gastric mucosal damage induced by acute exposure of ethanol. Protective effect of lcitrulline against ethanol induced gastric ulcer in rats. Rats 510 per group were treated orally with 1 ml of 100% ethanol or 3 ml of 47% ethanol or with 1 or 3 ml of saline. Drugs and chemicals ranitidine hcl rhcl was kindly donated by amoun pharmaceutical company. Apiaceaeumbelliferae, at doses of 250 and 500 mgkg body weight, was evaluated for antigastric ulcer activity using various experimental gastric ulcer models in rats.
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